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General information

Glimepiride belongs to a large group of antidiabetic drugs, sulfonylureas, which includes maninil, diabeton, and others. It is secretagogues, its action is to stimulate the work of pancreas.

Indications

Before use Glimepiride, please consider the following information.

The drug improves the sensitivity of muscle and adipose tissue to the action of native insulin, may reduce the synthesis of glucose by the liver. Moreover, Glimepiride has not very pronounced antithrombotic effect, and it also reduces the amount of free radicals.

Dosage

Cheap Glimepiride is available in tablets of 1, 2, 3 and 4 mg. Glimepiride is taken once a day. Therapy begins with 1 mg per day, the effect of which can be evaluated in 1-2 weeks. If glucose levels are not normalized, the dose can be increased by 1 mg. Further control and correction of the dose is done in similar way, increasing the dose to 1 mg per day. On average, the dose does not exceed 1-4 mg per day, but there are patients where the drug helps only in dose of 6 mg, this dose is also the maximum daily dose. Before use Glimepiride, you should know that the treatment with the medicine requires individual dosage.

Glimepiride is taken before a meal, as it takes time before the drug takes effect. It is important not to miss a meal after taking the drug. Because it has an effect to improve insulin sensitivity, one could then eventually require a dose reduction. Like all sulfonylureas, Glimepiride can cause hypoglycemia condition, so you need to be careful when changing the lifestyle, increasing physical activity, etc.

Glimepiride is very well combined with metformin, so they are often prescribed together

Side effects

If you want to use Glimepiride, you should also know its side effects before purchase. Consult your physician for prescription and consulatation.

Side effects include:

  • Hypoglycemia;
  • Transient visual disturbances (temporary swelling of the lens );
  • Dyspeptic disorders (nausea, vomiting rarely );
  • Allergic reactions;
  • Hyponatremia;
  • Photosensitivity.

Glimepiride is not prescribed to pregnant and lactating women, children. With care patients with renal and hepatic impairment. It is recommended to consult your physician in case you notice one of the mentioned above side effects.

Thus, we can conclude that Glimepiride a medication with high efficiency, safe, because it uses small doses of the treatment, and it has a number of additional effects. But despite the effectiveness of the medication, the maximum effect of it is possible only if all the lifestyle changes that resulted in the emergence of diabetes.

Precautions

Before use cheap Glimepiride, you should know that taking oral hypoglycemic drugs is associated with a high mortality rate (resulting in disorders of the cardiovascular system ) compared to treatment with only diet or diet plus insulin. The patient should be informed of the potential risks and benefits of using Glimepiride and an alternative method of treatment with medication. Glimepiride treatment should be initiated and conducted under the supervision of a physician. The patient should take Glimepiride in prescribed time (usually at the same time every day ) and only in prescribed doses. To achieve the goal of treatment better control of blood glucose concentration it is necessary, except for receiving Glimepiride, comply with all the doctor’s recommendations on diet, regular exercise and, if necessary, in relation to weight loss.

Influence on the ability to drive vehicles and operate machinery. It is recommended to refrain from engaging in potentially hazardous activities that require attention and speed of reaction.

Overdose

Symptoms of hypoglycemia accompanied by conditions such as sweating, anxiety, tachycardia, hypertension, arrhythmia, headache, dizziness, nausea, vomiting, lethargy, drowsiness, depression, tremor. Treatment: glucose orally or intravenously. The patient should be monitored, because in some cases hospitalization is required.
In case of overdose, the patient must contact his physician as soon as possible. Before taking the medication, it is recommended to consult physician for the individual dosage.

Interactions

The following medication might interact with other drugs. Strengthening the hypoglycemic effect of the drug may occur when used in combination with the following drugs: insulin or other hypoglycemic agents.

Decrease of hypoglycemic effect of the drug may occur when used in combination with the following drugs: acetazolamide, laxatives, barbiturates.When co-administered with Glimepiride histamine H2-receptor, clonidine and reserpine as hypoglycemic effect may increase, or decrease.